Immunohistochemical features lymphoid tissue colonic mucosa of children with different phenotypic variants of Crohn’s disease

The aim of the study was to determine immunohistochemical features lymphoid tissue mucous membrane (MM) colon in children with different course Crohn’s disease. Methods: results IHC and morphometric analyzes colonic colony disease uncomplicated complicated are presented. Results: An important role ratio distribution subpopulations T-lymphocytes CO clusters is shown, depending on phenotypic variant In a favorable prognosis disease, immunoregulatory index (IRI) close normal predominance CD4 + T-lymphocyte population against background moderately increased number CD8 cells B-lymphocytes. IRI II group significantly due sharp increase +, CD19 B-lymphocyte link. Conclusion: A high level pronounced disproportion intrapopulation combined an unfavorable For minimal mismatch system characteristic IRI.